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Coronary artery disease, or CAD, is the most common form of heart disease and the leading cause of death for both men and women. It’s a progressive condition that is the result of plaque buildup, or atherosclerosis, in the arteries that supply blood and oxygen to the heart. It is also common for people with CAD to have peripheral artery disease, or PAD, a condition in which plaque buildup occurs in the arteries that supply blood to your limbs, usually your legs.